Chicken Alfredo Lasagna Recipe

If you’re craving something creamy, comforting, and a little bit elevated from your usual pasta night, you’re going to absolutely adore this Chicken Alfredo Lasagna Recipe. It’s my go-to when I want all the indulgence of traditional lasagna but with a luscious, cheesy Alfredo twist and tender chicken that brings a welcome change from the usual. Trust me, once you try this, your family—and maybe even your picky eaters—will be asking for it on repeat!

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Ingredients You’ll Need

These ingredients come together beautifully for a dish that balances savory chicken, vibrant spinach, and that unforgettable Alfredo sauce. Grab quality Parmesan cheese for the best flavor, and make sure your lasagna sheets are suited for boiling—not the no-boil kind—since they’re the base of those perfect, tender layers.

• Chicken tenders or breast: I prefer tenders because they cook evenly and stay tender, but breasts work great too.
• Olive oil and spices: Basics like garlic powder, Italian seasoning, cayenne, salt, and pepper amp up the flavor.
• Unsalted butter: For a creamy base in the sauce, unsalted means you can control saltiness.
• Onion and garlic: Sautéed until soft and fragrant, these build layers of flavor in the sauce.
• All-purpose flour: Creates the roux to thicken your Alfredo sauce perfectly.
• Whole milk and heavy cream: Blend creaminess and richness in the sauce you’ll fall in love with.
• Parmesan cheese: Freshly grated is a game changer—way better than pre-grated!
• Fresh spinach: Adds brightness and a lovely color contrast.
• Lasagna sheets: Boiled to al dente and lightly oiled so they don’t stick.
• Shredded mozzarella cheese: Melty, gooey goodness for topping and layers.
• Fresh parsley: The finishing touch for color and a hint of freshness.

Variations

I love how versatile this Chicken Alfredo Lasagna Recipe is! Whether you want to switch up the protein or sneak in veggies, this recipe is a perfect canvas. Don’t be afraid to get creative and make it your own.

• Using mushrooms: I sometimes sauté mushrooms along with the spinach for extra earthiness and texture—it’s a crowd-pleaser.
• Low-carb version: Swap lasagna sheets for thinly sliced zucchini or eggplant to keep it light but still delicious.
• Spicy kick: If you like heat, add a pinch of crushed red pepper or more cayenne in the chicken seasoning for a fun twist.
• Dairy-free: Use coconut cream and a dairy-free cheese substitute; it’s not quite the same but still tasty in a pinch.

How to Make Chicken Alfredo Lasagna Recipe

Step 1: Boil Your Lasagna Sheets to Al Dente Perfection

Start by boiling the lasagna sheets according to package instructions until they’re al dente—firm but cooked through. This part is crucial because overcooked sheets get mushy in the oven, and undercooked ones won’t soften nicely. Toss them with a bit of oil as soon as they’re drained to keep them from sticking together—I’ve learned this the hard way after many a stuck-in-a-bowl mishap!

Step 2: Season and Sear the Chicken Tenders

Coat your chicken with olive oil, salt, pepper, cayenne, garlic powder, and Italian seasoning. I love the blend of spices here because it’s simple but flavorful and complements the creamy sauce beautifully. Heat your skillet—cast iron if you’ve got one—and cook them over medium-high heat until just cooked through with a nice sear, about 5 minutes per side. Resting them for 5 minutes afterwards lets the juices settle, so when you chop them into chunks, they stay juicy and tender.

Step 3: Whip Up the Spinach Alfredo Sauce

This sauce is the heart and soul of the recipe. Start by melting butter and sautéing finely chopped onion until translucent—this adds a subtle sweetness. Toss in the garlic, salt, pepper, chili flakes, and Italian seasoning, and let the spices bloom for a minute. Stir in the flour and toast it well, which helps thicken the sauce later without any floury taste. Slowly whisk in the milk and cream, then bring the heat down—stir until it thickens to a velvety texture. Remember, it shouldn’t be too thick because it’ll continue cooking in the oven. Finish by folding in chopped spinach and freshly grated Parmesan—this turns the sauce into a smooth, flavorful dream.

Step 4: Layer Your Lasagna Like a Pro

Preheat your oven to 375°F and grease your lasagna dish lightly. Start spreading a spoonful of sauce on the bottom to prevent sticking. Place about 3 lasagna sheets side by side—don’t overlap—and spoon over a generous layer of sauce, then a third of your chicken, and sprinkle with mozzarella. Repeat this second and third layers the same way. The final layer is lasagna sheets topped with the remaining sauce and cheese. One trick I picked up is poking toothpicks into the dish before covering with foil to create “tents” so the foil doesn’t stick to the cheesy top—game changer!

Step 5: Bake Until Bubbly and Golden

Bake covered for about 40 minutes so all those flavors meld beautifully. Then, remove the foil and broil for just 2-3 minutes to get that irresistible golden-brown crust on top—watch closely so it doesn’t burn! Let the lasagna rest outside the oven for 15 minutes; this lets it set and makes cutting cleaner without gooey messes.

How to Serve Chicken Alfredo Lasagna Recipe

Garnishes

I always garnish with freshly chopped parsley because it adds a fresh, vibrant pop of color and a mild herbal note that balances the richness of the lasagna perfectly. A little extra sprinkle of Parmesan on top after baking is a nice touch, too.

Side Dishes

To keep the meal balanced, I like serving a crisp green salad with a light vinaigrette alongside, or some roasted asparagus for a bit of crunch and earthiness. Garlic bread also pairs wonderfully if you want to indulge even more.

Creative Ways to Present

For special occasions, I like making individual servings in mini casserole dishes – it feels elegant and fuss-free for guests. You can also sprinkle toasted pine nuts or a drizzle of truffle oil on top for a gourmet upgrade that always wows my dinner guests.

Make Ahead and Storage

Storing Leftovers

I store leftovers tightly wrapped with plastic wrap and then foil in the fridge. It keeps the lasagna moist and prevents it from picking up other fridge smells. I find it stays delicious for up to 4 days, which is perfect for easy reheats throughout the week.

Freezing

I’ve had great luck freezing this Chicken Alfredo Lasagna Recipe in airtight containers. Just let it cool completely before freezing. When you’re ready to eat, thaw overnight in the fridge to keep that creamy texture intact.

Reheating

Reheat leftovers in the oven at 350°F covered with foil to prevent drying out, usually about 20-25 minutes from cold. If you’re in a hurry, the microwave works too but keep it covered and heat in short increments to keep the sauce creamy and avoid tough spots.

FAQs

Final Thoughts

I absolutely love how this Chicken Alfredo Lasagna Recipe brings all my favorite comfort foods into one dish. It’s creamy, cheesy, and packed with flavors that feel special but are actually easy to pull off on a weeknight or for a casual dinner party. Over time, I’ve tweaked it to maximize the tenderness of the chicken and richness of the sauce, making it a staple in my recipe box. I can’t wait for you to try it—once you do, you might find it becoming your new family favorite too!

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